LC Method for the Estimation of Edaravone in Bulk and its Pharmaceutical Dosage Form

An accurate, sensitive, selective and precise HPLC method was developed for the development and validation of Edaravone in bulk and its pharmaceutical dosage form. The HPLC was carried out with mobile phase containing methanol. UV - Visible Spectroscopic determination was carried out at an absorption maximum of 243 nm using methanol as a solvent. The linearity werefound to be in the range of 0.1-30 µg/ml. Validation of proposed method has been carried out with respect to linearity, accuracy, precision, specificity, selectivity and robustness. Due to sensitivity, reproducibility and accuracy of methods, our thought of interest that the proposed methods will be useful for the routine quality control analysis and quantification of drug in bulk and pharmaceutical dosage form.

Keywords: Edaravone; HPLC; Validation.